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Dr Wendy Jones, Pharmacist
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Pharmacist
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Miscarriage and Pregnancy Loss

Medication during pregnancy loss

In Short
Ectopic pregnancies

Miscarriage

Prevention of recurrent miscarriage

Terminating a pregnancy

Ectopic pregnancies

An ectopic pregnancy is when a fertilised egg implants itself outside the womb, usually in one of the fallopian tubes. The pregnancy is not viable and the mother’s health is at risk if it continues. Sadly, the pregnancy has to be removed, either surgically, often as an emergency, or by using medication (normally methotrexate).

Miscarriage

Sometimes longed-for pregnancies end in miscarriage. The signs of miscarriage may be vaginal bleeding and cramps in the lower abdomen. You may need to take painkillers as you would for period pains. Sometimes not all the ‘products of conception’ may be expelled. You may need an operation to make sure the womb is clear, or you may be given the same drugs as you would for a termination. You may be offered a two-stage medication procedure: a mifepristone 200mg tablet orally followed 24–48 hours later by misoprostol 800 micrograms. This is usually given as a pessary but can be a tablet under the tongue. You may also be given painkillers and antibiotics. Give yourself time to grieve – this was the loss of a dream as well as a baby. It is common to feel guilty as well as sad. Many families don’t share the news of a pregnancy until after the 12-week scan ‘just in case’, but if something happens you need friends to care for you, so consider letting them know what’s happened.

Prevention of recurrent miscarriage

Some women experience recurrent miscarriages and need to take medication in order to protect the foetus. This may include the use of 75mg aspirin and progesterone pessaries.

Terminating a pregnancy

Some mothers find themselves pregnant unexpectedly and in such circumstances that they feel that they cannot continue with the pregnancy. In this situation, you may be offered a surgical termination. You may also be offered a two-stage medication procedure: a mifepristone 200mg tablet orally, followed 24–48 hours later by misoprostol 800 micrograms. This is usually given as a pessary but can be a tablet under the tongue. You may also be given painkillers and antibiotics.

Further information and references

Extracts taken from “Why Mothers Medication Matters” Jones W Pinter and Martin 2017

  • Bastow BD et al, Teratology and Drug Use During Pregnancy
  • Cain MA, Bornick P, Whiteman V. The maternal, fetal, and neonatal effects of cocaine exposure in pregnancy. Clin Obstet Gynecol. 2013;56(1):124-132.
  • Ebrahimi, N., Maltepe, C. and Einarson, A. ‘Optimal management of nausea and vomiting of pregnancy’ Int. J. Womens Health 2010; 2: 241–248.
  • Hale TW Medications and Mothers milk 2017 (online access)
  • Hudak, M.L., Tan, R.C., ‘The Committee on Drugs and The Committee on Fetus and Newborn. Neonatal drug withdrawal’. Pediatrics 2012;129(2):e540-60.
  • Koren, G., Moretti, Kapur, B. ‘Can Venlafaxine in Breast Milk Attenuate the Norepinephrine and Serotonin Reuptake Neonatal Withdrawal Syndrome?’ JOGC 2006 April; 28(4):299-302
  • Mazzotta, P.L., Magee, L.A. ‘A risk-benefit assessment of pharmacological and nonpharmacological treatments for nausea and vomiting of pregnancy’. Drugs 2000;59(4):781-800. As reported in Festin, M. ‘Nausea and vomiting in early pregnancy’. BMJ Clin Evid 2009; 2009: 1405.
  • National Institute for Health and Clinical Excellence (NICE) 2008. Maternal and Child Nutrition, Improving the nutrition of pregnant and breastfeeding mothers and children in low-income households.
  • National Institute for Health and Clinical Excellence (NICE) 2013. Clinical Knowledge Summary Nausea and Vomiting in Pregnancy.
  • Prevention of rickets and vitamin D deficiency in Birmingham: the case for universal supplementation.
  • SACN Update on Vitamin D 2007.
  • SACN Vitamin D and Health 2016
Support organisations

Bumps – best use of medicines in pregnancy

Mother to Baby medication and more during pregnancy and breastfeeding (part of OTIS)

Mother to Baby medication and more during pregnancy and breastfeeding (part of OTIS)Motherisk – treating the mother, protecting the unborn

DISCLAIMER
This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Essential Parent has used all reasonable care in compiling the information from leading experts and institutions but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details click here.